Fig. 1. FTY720-P increases the activity of the Na⁺/K⁺ ATPase via S1PR3. (A) Effect of FTY720-P (7.5nM. 2hours) on the activity of the hepatic Na⁺/K⁺ ATPase in presence of (B) a S1PR3 antagonist (CAY10444,17.4 µM, added 30min before FTY720-P) and agonist (CYM5541; 2 µM, 2hours), and (C) a S1PR2 antagonist (JTE-013; 1 µM, added 30min before FTY720-P) and agonist (CYM5520; 2.5 µM, 2hours) . Values are means ± SEM of 3 observations. Bars not sharing a common letter are significantly different from each other at p< 0.001.